publications

a list of current publications.

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning
Estevam GO, Linossi EM, Rao J, Macdonald CM, Ravikumar A, Chrispens KM, Capra JA, Coyote-Maestas W, Pimentel H, Collisson EA, Jura N, Fraser JS
Elife, 2024
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A Suite of Foundation Models Captures the Contextual Interplay Between Codons
Naghipourfar M, Chen S, Howard MK, Macdonald CB, Saberi A, Hagen T, Mofrad M, Coyote-Maestas W, Goodarzi H
Biorxiv, 2024
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  • Biorxiv Preprint v617568: 617568

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain
Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
eLife, 2024
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Deep mutational scanning of EccD3 reveals the molecular basis of its essentiality in the mycobacterium ESX secretion system
Trinidad DD, Macdonald CB, Rosenberg OS, Fraser JS, Coyote-Maestas W
Biorxiv, 2024
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The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics
Sook Wah Yee#, Christian Macdonald#, Darko Mitrovic#, Xujia Zhou, Megan L. Koleske, Jia Yang, Dina Buitrago Silva, Patrick Rockefeller Grimes, Donovan Trinidad, Swati S. More, Linda Kachuri, John S. Witte, Lucie Delemotte, Kathleen M. Giacomini, Willow Coyote-Maestas (#Equal contributions)
Molecular Cell, 2024
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Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage
Rao J, Xin R#, Macdonald CB#, Howard M, Estevam GO, Yee SW, Wang M, Fraser JS, Coyote-Maestas W, Pimentel H (#Equal contributions)
Genome Biology, 2024
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Molecular basis of proton-sensing by G protein-coupled receptors
Matthew K. Howard*, Nicholas Hoppe*, Xi-Ping Huang, Christian B. Macdonald, Eshan Mehrota, Patrick Rockefeller Grimes, Adam Zahm, Donovan D. Trinidad, Justin English, Willow Coyote-Maestas, Aashish Manglik
Biorxiv, 2024
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Deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology
Macdonald CB, Nedrud D, Rockefeller Grimes P, Trinidad D, Fraser JS, Coyote-Maestas W
Genome Biology, 2023
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Still rocking in the structural era: a molecular overview of the Small Multidrug Resistance (SMR) transporter family
Burata OE, Yeh TJ, Macdonald CB, Stockbridge RB
Journal of Biological Chemistry, 2022
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The structural basis of promiscuity in small multidrug resistance transporters
Kermani AA#, Macdonald CB#, Burata OE, Koff BB, Koide A, Denbaum E, Koide S, Stockbridge RB (#Equal contributions)
Nature Communications, 2020
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Guanidinium export is the primal function of SMR family transporters
Kermani AA, Macdonald CB, Gundepudi R, Stockbridge RB
Proceedings of the National Academy of Sciences, 2018
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A topologically diverse family of fluoride channels
Macdonald CB & Stockbridge RB
Current Opinion in Structural Biology, 2017
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Antineoplastic Agents. 600. From the South Pacific Ocean to the Silstatins
Pettit GR, Arce PM, Chapuis JC, Macdonald CB
Journal of Natural Products, 2015
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Antineoplastic Agents. 599. Total Synthesis of Dolastatin 16
Pettit GR, Smith TH, Arce PM, Flahive EJ, Anderson CR, Chapuis JC, Xu JP, Groy TL, Belcher PE, Macdonald CB
Journal of Natural Products, 2015
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